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Herpes Simplex Virus (PATHOGENESIS (EPIDEMIOLOGY (Distribution (currency…
Herpes Simplex Virus
PATHOGENESIS
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MECHANISM OF INFECTION
- HSV attempts to evade the immune system by downregulating MHC-I expression in infected keratinocytes
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IMMUNOLOGY
INNATE IMMUNE RESPONSE
- production of type I interferons(IFN)
- cytokines production recruit natural killer cells, T and B cells
- plasmacytoid DCs -secrete IFNalpha
- NK cells -kill infected cell and produce IFNgamma
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ADAPTIVE IMMUNE RESPONSE
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- CD8 -killed infected keratinocytes
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