Please enable JavaScript.

Coggle requires JavaScript to display documents.

COLON (linkovi (ppt (http://www.primeoncology.org/online-education/solid…

- - - - CALGB
        
        tjelovježba
        
        aspirin
        
        smanjuje upalu, angiogenezu
        
        trilsi za 40% pov CSS
      - vit D
        
        CSS 40%, 2poz (RCT), 3 neg (RCT), manje studije poz HR 0.60
  - - - DPD
      - UGT1A1
  - - - https://www.youtube.com/watch?v=C3lWwBslWqg
      - https://www.youtube.com/watch?v=uDcQbk78CSw&t=14s
    - - https://www.youtube.com/watch?v=BNAgri-C8Y0
- - - - vrste
        
        radikalne
        
        palijativne
      - borderline
        
        kemoth
        
        EPOC, nev EPOC FOLFOX+bev, PFS SS kod borderline EPOC
        
        3 ckl FOLFOX+/- biološka th
        
        EORTC BOS2
        
        https://www.google.ba/search?q=eortc+BOS2&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiO1djd6MTZAhUG66QKHRK6CVgQ_AUICigB&biw=1229&bih=607#imgrc=R3g1KmNEl4mHnM:
        
        EORTC 40983
        
        https://www.google.ba/search?q=EORTC+40983&source=lnms&tbm=isch&sa=X&ved=0ahUKEwip3MWt6MTZAhUKDewKHUCBDiUQ_AUICigB&biw=1229&bih=607#imgrc=3PJ32iI7al7iTM:
        
        https://www.google.ba/search?q=EORTC+40983&source=lnms&tbm=isch&sa=X&ved=0ahUKEwip3MWt6MTZAhUKDewKHUCBDiUQ_AUICigB&biw=1229&bih=607#imgrc=b6GTmA0U3G8sQM:
    - - kemoth
        
        studije
        
        Oxali, level
        
        MOSAIC, 96 ne efektivna, 40% ima neuropatiju
        
        2200 pts, DFS 20%, OS 20%
        
        MRC C-07
        
        XELOXA
        
        stariji
        
        ACIENT, nSS DFS, OS
        
        Heler,, poz OS, DFS
        
        ako su dobrog općeg stanja, maratonci
        
        meta analize
        
        neg
        
        IMPAKT
        
        Kanadska
        
        Intergrup
        
        poz
        
        SEER analiza
        
        QUASAR
        
        prog neg, +PFS
        
        meta analiza, 3000 pts, 7 studija
        
        benefit apsolutni OS 5%, DFS 12%
        
        adj th
        
        Inetrgrop 035, Moertel, 1900, prvi dokazi BENEFITa
        
        https://www.google.ba/search?q=Intergroup+035+study&tbm=isch&source=lnms&sa=X&ved=0ahUKEwjBneXv4sTZAhWIsKQKHUEuCl0Q_AUICigB&biw=1229&bih=607&dpr=1.56#imgrc=YKmOj4oRafQMwM:
        
        Intergruo 0089
        
        https://www.google.ba/search?q=Intergroup+0089&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjvjYah48TZAhWIzKQKHXhEDf0Q_AUICigB&biw=1229&bih=607#imgrc=KcNGankgoOq3YM:
        
        Gill, 2004, +DFS s dodatkom kemoth
        
        https://www.google.ba/search?q=gill+2004+et+al+colon+cancer&source=lnms&tbm=isch&sa=X&ved=0ahUKEwi9lsPl48TZAhVC6qQKHSLXBIoQ_AUICigB&biw=1229&bih=607#imgrc=VUK3cyPTSf2JHM:
        
        kapecitabin
        
        XACT
        
        https://www.google.ba/search?q=XACT+study&tbm=isch&source=lnms&sa=X&ved=0ahUKEwj7pK7W5MTZAhXKzaQKHf8-ACQQ_AUICigB&biw=1229&bih=607&dpr=1.56#imgrc=VfvBNum-iF70LM:
        
        FLOX
        
        NABP C07
        
        https://www.google.ba/search?q=NSABP+c+07&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjk3Nrk6sTZAhXMDewKHV0PBfoQ_AUICigB&biw=1229&bih=607#imgrc=I8d6iLuCISrC5M:
      - prognostički čimbenici
        
        standardni
        
        analiza
      - trajanje terapije
        
        IDEA ptojekt, st III, <12000 pts, t3/T41
        
        T3N1
        
        6 mj 5FU/LV
        
        3 mj FOLFOX
        
        T4N2
        
        6mj FOLFOX
      - neuspjesi
      - radioterrapija
        
        intergrup
    - - inoperabilni
        
        sistemska th
        
        stanična
        
        kemoterapija
        
        općenito
        
        vrste
        
        ihodi
        
        način davanja
        
        2 more items...
        
        mix
        
        vrste
        
        2 more items...
        
        peritonum sekundarizmi
        
        općenito
        
        4 more items...
        
        studije
        
        5 more items...
        
        novi klinci
        
        TAS 102
        
        2 more items...
        
        Irinotekan
        
        CALGB C89803
        
        3 more items...
        
        kemoth
        
        FOLFOXIRI
        
        2 more items...
        
        target terapiju
        
        VGFR
        
        lijekovi
        
        4 more items...
        
        EGFR
        
        lijekovi
        
        2 more items...
        
        mix
        
        studije
        
        4 more items...
        
        HER
        
        poz 5%
        
        studije
        
        2 more items...
        
        BRAF
        
        BEACON, f2, 34 pts, BRAF+MEK, poz impuls, RR
        
        1 more item...
        
        10-15%
        
        predavanje
        
        2 more items...
        
        holiday
        
        KT pa obs
        
        COIN -cap/5FOLOX 12tj-kt vs obs
        
        1 more item...
        
        OPTIMOX-FOLFOX-samo ona nije poz
        
        1 more item...
        
        MRC-5FU/LV
        
        1 more item...
        
        GISCAD-FOLFIRI
        
        1 more item...
        
        KT 12 tj
        
        KT pa intermitentni Ox
        
        OPTIMOX1- FOLFOX+bev do PD vs 5FU/LV 12 tj pa FOLFOX
        
        1 more item...
        
        CONCEPT-FOLFOX+bev do PD vs 5FU/LV 16tj pa alternacija FOLFOX
        
        1 more item...
        
        OPTIMOC, MRC COIN, NO 1966
        
        BEZ Oxali LOŠIJI ISHOD
        
        okoliš
        
        CPI
        
        PD1
        
        Nivo
        
        2 more items...
        
        Penbro
        
        4 more items...
        
        PDL1
        
        Atezo - cobi, MSS, 80 pts, RR7%, 12 mj OS 40% (regora 20%)
        
        u tijeku, IMBlaze 370, f3 (Atezo+cobi), 2 L kemoth prethodno
        
        1 more item...
        
        1L
        
        1 more item...