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Developmental Toxicology (Examples: (Diethylstilbestrol (DES), Ethanol,…
Developmental Toxicology
Outcomes that lead to abnormal development
Structural
Growth retardation
Functional impairment
Embryonic lethality
Teratogen - compound that causes developmental issues
Examples:
Diethylstilbestrol (DES)
Ethanol
Thalidomide
Tobacco smoke
Cocaine
Retinoids (Vitamin A)
Valporic Acid
Angiotensin System
Wilson's Principle of Toxicology
Critical Timing - Susceptibility and Endpoints
Key stages
Preimplantation
Gastrulation - formation of 3 primary germ layers
Fertilization
Organogenesis
Gameotogenesis