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EXTRACTION METHOD IN PHARMACEUTICAL ANALYSIS (Why conduct extraction? (For…
EXTRACTION METHOD IN PHARMACEUTICAL ANALYSIS
What is extraction?
A technique to separate a desired substance in a mixture
Why conduct extraction?
To obtain pure compound for analysis
To remove interfering materials that can damage instrumentation
For Analysis
Suspensions/solutions
Dyes natural pigments
Anti-bacterial preservatives
Creams/ointments
Surfactants
PEG
Oily triglycerides
Tablets/capsules
Colorant
used has high potential for interference
Extraction Mehanisms
Partitioning
Ion-pair extraction
Acid-Base extraction
Extraction Methods