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PRIONS (characteristics (shape (resistant to: (radiation, chemicals,…
PRIONS
characteristics
acellular
infectious
smol
shape
resistant to:
radiation
chemicals
enzymes
can cause neurological disease
transmissible spongiform encephalopathy
disease via infectious prions
progressive neuropathology
long incubation
animals and humans
no treatment
prion examples
mad cow
scrapie
sheep and goats
chronic wasting disease
bone spongiform disease
human TSEs
kuru
CJD
1 in a million
sporadic
genetic
rarely infectious
variant CJD
young median age
prion hypothesis
infectious normal > mixed > conversion to infection
stick together in long strings of badly folded prion proteins