Please enable JavaScript.
Coggle requires JavaScript to display documents.
Pseudogout and Paget's Disease of Bone (Pathophysiology / Presentation…
Pseudogout and Paget's Disease of Bone
Treatment
High dose NSAID or colchicine
Prednisiolone
Aspiration of joint
Pathophysiology / Presentation
Attacks are very painful
Hot joint and fever
Shedding of crystals into the joint cause acute synovitis and is more common in elderly women
Deposition of calcium pyrophosphate in articular cartilage and periarticular tissue. This causes a radiological appearance of chonedrocalcinosis (linear calcification parallel to the articular surface)
Definition: Pseudo-gout is a condition that is characterized by the deposition of calcium pyrophosphate crystals on a joint surface
Pathophysiology
Formation exceeds resorption. BUT the new woven bone is weaker than normal bone meaning that there is a deformity and increased fracture risk
Symptomatic silent disease
Increased osteoclastic bone resorption followed by formation of weaker new bone and increased blood flow and fibrous tissue
Definition: Paget's Disease of the Bone : this is a condition that is characterized by a focal disorder of bone remodelling
Difference between Paget's and Osteoporosis. In paget's you have increased bone breakdown but you also increased poor abnormal remodeling process
Epidemiology/ RF
More common in Europe and N America
More common in Females
Incidence increases with age
RF: latent viral infection (RSV or measles) as it means osteoclasts are susceptible . A strong family history of the condition
Epidemiology
RF:old age, diabetes, osteoarthritis, trauma
Generally affects more elderly women
RF: metabolic disease: hyperparathyroidism and hemochromatosis
Clinical Presentation:
Bone pain and joint pain
Deformities i.e. bowed tibia and skull changes
Common sites are in the lumbar,thoracic, skull and tibia
Neurological compression : deafness and paraparesis with hydrocephalus.
Diagnosis
Positive bifringent crystals are under polarize light. REMEMBER that Pseudo gout = Positively Bifringent
X-Ray shows chonedrocalcinosis parallel to the articular surface
FLuid aspiration- you see small rhomboid crystals
Bloods- raised WCC count