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Lipid Metabolism (Categorized into 3 groups (powerful approach for…
Lipid Metabolism
Categorized into 3 groups
powerful approach for understanding lipid catabolism
Hyperlipidemias
Errors of fatty acid metabolism
Defects of cholesterol production and use
Lipids
Heterogeneous group of biomolecules
Insoluble in water
highly soluble in organic solvents
Provide backbone for phospholipids and sphingolipids
components of all biological membranes
Constituents of steroid hormones
ex. cholesterol
intracellular messengers
energy substrate
Hyperlipidemia
Common
Result from defective lipid transport mechanisms
Errors in the metabolism of fatty acids
much less common
Fasting or prolonged aerobic exercise
fatty acids mobilized from adipose tissue
Become major substrate for energy production
liver
skeletal muscle
cardiac muscle
Major steps in pathway
uptake and activation of fatty acids by cells
transport across the outer and inner mitochondrial membranes
entry into the B-oxidation spiral in the mitochondrial matrix
defects in each step have been described
defects of fatty acid oxidation (FAO) most common
Defects of cholesterol production and use