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human carbonic anhydrase VI (connections (salty taste (CA VI was inversely…

- - - - physiological significance of a complex between HSA and HCA VI is still unclear (fisher et al 2006)
      - HCA VI and HSA have some affinity for each other in saliva and/or in solution and that this interaction is possibly because HCA IV is glycosylated (Feldstein & Silverman, 1982 ▶; Thatcher et al., 1998 ▶).
        
        interaction is most likely to be mediated by the oligosaccharide moiety attached to HCA VI as it is glycosylated (fisher et al 2006)
    - - there was a tendency for individuals with a higher BMI to present higher CA VI levels Lamy et al 2015
        
        However, if it is assumed that the reports of studies relating PRPs, cystatin S, and CA VI abundance with bitter taste sensitivity are correct, this surgical procedure may be suggested as being related to a decrease in bitter taste sensitivity
      - under fasting conditions, salivary lipolysis was lower in obese vs normal-weight subjects, whereas proteolysis and carbonic anhydrase VI were higher Vors et al 2015
    - - A gene product, CAVI-a, which represents the only secreted isozyme in the CA family, is restricted to salivary acinar cells (Parkkila, 2000). Under stress conditions where CHOP is activated, a truncated CAVI-b isozyme is generated that lacks a secretion signal (Sok et al., 1999). Matthews et al 2014
      - CAVI-b lacks a canonical nuclear localization sequence, the distribution is likely to reflect size rather than targeting. We found that CAVI-b was induced by ER stress (Fig. 2), and that the stress induction of CAVI-b in neurons was absolutely dependent upon CHOP (Fig. 4). MAtthews et al. 2014
        
        This is likely due to the lack of a small but well-conserved region in the N-terminus of CAVI-b. Hence, the role of CAVI-b is probably not related to acid-base balance.
  - - - Because a high amount of CA VI is supplied to the adult gastrointestinal tract daily in the saliva (13), and the newborn infant's saliva secretion is low because of the immaturity of the salivary glands (14, 15), we set out to ascertain whether there is any other source of CA VI that could ensure a high concentration of the enzyme in the postnatal alimentary canal (karhumaa et al 2001)
      - Although the exact physiological significance of milk CA VI remains undefined here, we suggest that, as an acid-resistant enzyme (11), it may function as a trophic growth factor in the infant alimentary tract, which undergoes pronounced growth and functional maturation during the immediate postnatal period. karhumaa et al 2001
    - - CA VI binds to immunoglobulins A and G (8, 32), although its role in immunological responses has not been determined Karhumaa et al 2001