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SERONEGATIVE SPONDYLOARTHRITIS (psoriatic arthritis (skin (ears, umbilicus…
SERONEGATIVE SPONDYLOARTHRITIS
ankylosing spondylitis
SPINEACHE
sausage digit (dactylitis)
psoriasis
inflammatory back pain
calcification of anterior longitudinal ligaments and between vertabrae
NSAID responsive
enthesitis of heel
arthritis
HLA B27
molecular mimicry
misfolding theory
unfolds and accumulates in ER, triggering T cells
heavy chain homodimer hypothesis
eye (uvitis)
Crohn's/Colitis/ raised CRP
treatments
NSAIDs
physio
TNF inhibitors
use MRI rather than X ray to detect disease earlier
reactive arthritis
immune system attacks self cells that look like a recent infection
usually a GI/GU infection within the last 2/52
sterile inflammation of the synovial membrane, tendons and fascia
Can't See
sterile conjunctivitis
Can't pee
sterile urethritis
Can't climb a tree
arthritis of the large joints
psoriatic arthritis
skin
ears
umbilicus
genital
nails
pitted
thick
inflammation of joints and tendon sheaths
sudden, painful onset
may cause arthritis mutilans
treatment
TNF inhibitors
interleukin blocker
enteropathic arthritis
associated with Crohn's and UC
non-erosive
asymmetric lower limb arthritis
reflects activity of bowel disease