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Mycobacteria (Important species and host/diseases (M. tuberculosis (MTBC) …
Mycobacteria
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Mycobacterium bovis
Pathogenesis
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Granuloma formation = inflam response in lungs, recognizable tubercle
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Eradication programs worldwide, some successful
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Diagnosis
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Reactive 30-50 days after infection. Delayed hyper-sensitivity to M. bovis tuberculoprotein. Purified protein derivative injected intradermally, PPD injected and site checked a few days later.
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M. avium, subsp. Paratuberculosis (MAP)
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Young animals more susceptible, ingestion of contaminated milk
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M. lepraemurium
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Worldwide, endemic in wild rodents in some parts of world
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Typical habitats
Lipid rich walls --> hydrophobic, resistance to adverse environments
Environmental found in soil, vegetation and water sources
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Acid-fast organism
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Cell wall contains peptidoglycan, lipids and mycolic acid within layer
High lipid and mycolic acid protects from acids, alkalis and digestion in macrophages. Impedes entry of molecules, slow growing, responsible for inflam response
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Typing
Ziel-Neelsen (ZN) method used to stain, stain red
Differentiation uses: Cultural characteristics, biochemical tests, animal innoculation and molecular techniques
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