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Cis-P Tau is induced in clinical and preclinical brain injury and…

- - - - Found int cortical axons and CSF
      - USed mouse models with sever or repetitive TBI, show P-Tau elimination following antibody treatment.
        
        Administered immediately or at delayed intervals
        
        Attenuates development of neuropathology
        
        Therefore, cis P TAU contributes to short term and long term sequelae of TBI but is neutralized by antibody.
        
        HOW? WHAT?
- - - - Removal of N-Terminal or C-Terminal region of protein by proteolysis or by manipulation of the structural gene.
    - - Group of protein athat attach and detach from other proteins in cells to modify function.
        
        Nuclear-cytosolic transporwt, Transcriptional regulation, apoptosis, protein stability, stress response, progression theourhg the cell cycle.
    - - Protein staility
      - Protein localization
      - Metabolism and Apoptosis
      - Protein synthesis
      - Cancer?
- - - - Blocks progression of tau pathology?
      - enters neuronsvia Fcy receptors to target intracellular cis P tau for TRIM21 degradation
      - Proof of principle for using antibodies to remove toxic proteins from the brain
- - - - 1hour to 1 week compared to controls, CIS, Trans, DAPI
        
        No trans TAU?
    - - silver staining for axonal injury in the cortex
    - - Antibody for early, middle and late stage tau pathology
  - - - Ptau levels in samples