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Proposal (Gut brain axis (Gut microbiome (Methods (germ free animals (have…

- - - - germ free animals
        
        have higher plasma tryptophan
        
        (so less 5-HT in brain?)
        
        Also higher 5-HT in plasma
      - probitoic supplementation
      - antibiotics
      - Feacal transplantation
      - deliberate infection
    - - Initial/postnatal
        
        Received during delivery
        
        C-section have more skin bacteria
        
        Preterm lack some bacteria
        
        Nurtrition
        
        breast milk
        
        Other factors
        
        genotype
        
        geography/culture
        
        infection
        
        antibiotics
        
        Probiotics
        
        mental health benefits might accrue with normal developmental patterns and increased risk for psychopathology arises from detrimental colonisation patterns
        
        through tryptophan/serotonin metabolism?
      - Adult
        
        relatively stable
        
        Individual differences
        
        maybe a core microbiome
        
        Influenced by
        
        nutritional factors
        
        Antibiotics can permanently alter it
      - Elderly
        
        more between subject variability
        
        factors
        
        diet
        
        residence location
        
        adverse health outcome
        
        Related to serotonin?
  - - - Triptophan in food
        
        converted to 5-HTP by TPH
        
        Converted to 5-HT by AAAD