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Chapter 4 (Action Potential Steps (Entry of Na+ ions depolarizes
neuron,…
Chapter 4
Action Potential Steps
- Entry of Na+ ions depolarizes
neuron
- Increase in gNa is brief, AP
duration is short
- Transient increase in gNa
- Restoration of negative potential aided by transient increase in gK during falling phase
- Membrane potential is
depolarized to threshold
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Voltage-Gated Na+ Channel: 4 domains, 6 subunits in each
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Hodgkin and Huxley used voltage clamp to measure sodium and potassium currents at different membrane voltages
Absolute Refractory Period: Na+ channels inactivated until membrane goes negative enough to deinactivate channels
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Spike Initiation Zone; Axon hillock, or in sensory neuron, near sensory nerve endings