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Bone pathology (anatomy (bone matrix (interstitium) (type 1 collagen…
Bone pathology
anatomy
see diagram in notes
bone matrix (interstitium)
type 1 collagen polymers
'ground substance'
osteoid
mineral
gives hardness
gives bone strength
flat bones
intramembranous
most other bones
cartilage precursors
modelling/remodelling of bone
remodelling
constant resorption of old bone and replacement by new (i.e. normal turnover)
allows repair of micro-fractures
relatively constant result - gradual loss of bone mass with age
modelling
change of shape and contour of a bone in response to normal growth, mechanical use, disease