Please enable JavaScript.
Coggle requires JavaScript to display documents.
FUN 12: Overactivation of immune response - Hypersensitivity +…
FUN 12: Overactivation of immune response - Hypersensitivity + Autoimmunity (ii)
Immune complex deposition
in type 3 hypersensitivity
in joints = arthritis
in kidneys = glomerular nephritis
vasculitis = inflamm cell activation
chronic inflamm - fibrosis - function loss
Hypersensitivity classification
1
IgE
target = soluble antigen
mast cell, basophil, eosinophil degranulation
asthma, allergies, rhinitis
2
IgG
target = cell-bound antigen
ADCC (macrophages + NKs)
drug allergies
complement
3
IgG
target = soluble antigen
immune complex deposition
complement
neutrophils, mast cells, macrophages
serum sickness, autoimmunity, hep C
1,2,3 = immediate
4 = delayed
subsequent exposure: faster
T memory cells
4
T cell driven
contact dermatitis
poison ivy, nickel
Autoimmunity
breakdown in tolerance
autoantibodies/ auto reactive T cells
how does it occur?
genetic predisposition
T reg cell/ APC defects
cellular damage
e.g. Lupus
decreased cell clearance
more self
affects more women
type 3
systemic
viral mimicry
viral antigen v similar to self antigen
Antibody driven
type 1 + 2
grave's, haemolytic anaemia, lupus, MG
can be organ specific or systemic
T cell mediated diseases
Type 1 diabetes
antigens of islet beta cells attacked
insulinitis
RA
cart/bone destruction
Th 17 - inflamm
MS
proteins in myelin sheath destroyed
Th 1+17
paralysis + ocular lesions
hashimotothyroiditis
thyroid attacked
hypothyroidism