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2-7 Molecular mechanisms of antibody diversity CONT... (REVIEW SOM RECOMB…
2-7
Molecular mechanisms of antibody diversity CONT...
Junctional diversity
P/N nucleotides
LINK GENES TO PROTEINS
VJ GENES OF L CHAINS
VDJ GENES OF H CHAINS
EXACTLY WHERE?
3RD SEG OF ???
CHALK BOARD 11 MIN
V
CATGGC
GTACCG
RSS --> CACAGTG
GTGTCAC (SP)(7)(23)(9)
cut b/w coding seq and hep
SHAPE MORE LIKE -->
CAT ^GG^ C
GTA vCCv G
EVENTU
CATGGC
GC
GTACCG
CG
2 more items...
HYDRO BONDS
J
GATTCG
CTAAGC
RSS --> (9)(23)(7)
no temp
can get spliced out if theres a frame shift
each exon must be divisible by three
How is V(D)J association different from isotype switching?
INTRON
no frameshift
WHAT IS?? VDJ??? or C REGION??
GET SPLICED OUT
DOESN'T FAIL
NO NONPRODUCTIVE CLASS SWITCHING
no cell death
V(D)J
both occur at DNA
som recomb
wouldn't want
gen spec
1 more item...
isotype
diff enzymes
occomplish diff
reg funct
all start igm and igd
1 more item...
Somatic hypermutation
timing
BCELLS MUT AT RAND
ONES THAT HAVE HIGHER AFFINITY SURVIVE
MUT OVER TIME
AFFINITY MATURATION
POPUL GOES THROUGH THIS
significance
NOT DURING DEV
MATURE BCELLS
AFTER INTERACTING W/ ANTIGEN
EXP
MOUSE IMUNNIZED
ISOLATE
SEQ DNA
FIND CHANGEDS FROM GERMLINE
MUTATIONS
IN ALL 3 CDRs
1 more item...
Mechanisms
of Ab diversity
time
location
REVIEW SOM RECOMB.
DNA
HSCs
and all other cells
ONLY IN DEV B CELLS
AND Ts
RNA PROCCESING
COMBINATORIAL DIVERSITY
INTRON REMOVAL
JUNCTIONAL DIVERSITY
TODAY ^
B/W HV SEG AND FR SEG