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IMMUNOLOGY (INNATE (MYELOID CELLS (DENDRITIC CELLS (RESIDE IN TISSUES,…

- - - - (2). ALLERGENS & HELMINTHS ELIMINATION
      - (3). GUARDS MUCOSAL SURFACE OF INTESTINES
      - (1). DEFENSE AGAINST INTRACELL. PATHOGENS
        
        AN EXAMPLE OF AN IMMUNE CELL INVOLVED IN THIS IS NK CELL
        
        CYTOTOXIC FUNCTION
        
        DIRECT KILLING BUT DEPENDENT ON WHETHER VIRUS CAN UP REGULATE MHC1
        
        NON-CYTOTOXIC FUNCTION
        
        NK CELLS RELEASE CYTOKINES TO RECRUIT CD4 CELLS
  - - - TOLL LIKE RECEPTORS
        
        HAVE DIFF. LIGANDS TO RECOGNISE DIFF. THINGS=THIS MAKES THEM SPECIFIC
        
        EG. TLR1 DETECTS GRAM -VE BACT.
      - LOCATED TO SAMPLE CELLULAR COMPARTMENTS CONTAINING DIFF. BACT.
    - - LOCATED IN PATHOGENS SO INNATE IMMUNE SYSTEM CAN RECOGNIZE SELF FROM NON-SELF
      - PRESENT EVEN WHEN PATHO. MUTATES & DURING ITS ENTIRE LIFE CYCLE
    - - LOCATED ON STRESSED/DAD CELLS WHICH INNATE CELLS RECOGNIZE
    - - LOCATED ON SURFACE OF IMMUNE CELLS TO RECOGNIZE PATHOGENS
  - - - SALIVA
      - MUCOSA
      - SKIN
      - TEARS
      - HCL
    - - MYELOID LINEAGE CELLS
  - - - RESIDE IN TISSUES
      - UTILISE TLRs & OTHER RECEPTORS TO RECOGNIZE ANTIGENS
      - MOST EFFICIENT APCs
      - MIGRATE TO LYMPHOID ORGANS & PRESENTS ANTIGENS TO T CELLS
- - - - PLASMA CELL
        
        IgD
        
        B CELL SURFACE MOLECULE
        
        IgG
        
        SECONDARY IMMUNE RESPONSE
        
        MOST ABUNDANT IN SERA
        
        IgA
        
        MOST ABUNDANT
        
        MUCOUS MEMBRANE
        
        IgE
        
        PARASITIC INFECTIONS & ALLERGIES
        
        IgM
        
        PRIMARY IMMUNE RESPONSE
        
        EARLY PRIM. RESPONSE
        
        SHORT LIVED
        
        LOW AFFINITY FOR ANTIGEN
        
        T INDEPEN. & DEPEN. RESPONSES
        
        MIGRATE TO SPLEEN & LYMPH NODE
        
        PREDOMINATE Ig is IgM & IgG
        
        LATE RESPONSE
        
        FROM GERMINAL CENTRES & MEMORY CELLS
        
        MIGRATE TO MAMMARY GLAND, GUT & BONE MARROW
        
        LONG LIVED
        
        SWITCHES BTW ANTIBODIES EG. IgM to IgA
    - - HELPER T CELLS HELP B CELLS PRODUCE ANTIBODIES AS WELL AS MACROPHAGES KILL ANTIGENS
      - CYTOTOXIC T CELLS KILL INFECTED CELLS
      - ONLY RECOGNIZE T ANTIGENS WHEN PRESENTED ON MHC