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MYC DEPLETION INDUCES A PLURIPOTENT DORMANT STATE MIMICKING DIAPUSE (1…
MYC DEPLETION INDUCES A PLURIPOTENT DORMANT STATE MIMICKING DIAPUSE
MYC
FAMILY MEMEBERS
L-Myc
ko is normal, but highlyquiscent HSCs survive the deletion of both c myc and N myc, while others HSCs are rapidly lost due t impared proliferation, differentiation and appoptosis
N-Myc
ko. dye before 11.5 due with neuroectodermal and heart defects
c-Myc,
ko. dye before 10.5 due to hematopoietic and placental defect
FAMILY OF TRANSCRIPTION FACTORS
FUNCTIONS
tumorigenesis
unrestricted proliferation
inhibition of differentiation
cell growth and metabolism
reduction of cell adhesion
essential for cellular reprogramming
maitains the balance between HSC self renewal and differentiation
1
ESCs cultured in serum plus lif showed high level of c myc and n myc than the ESCs cultured in 2i plus lif
experiments