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Cell Junctions (Anchoring Junctions (Hold cells to one another and to the…
Cell Junctions
Anchoring Junctions
Hold cells to one another and to the extracellular matrix
Cell-cell anchoring = cadherins
Cell-matrix = Integrins
Adherens Junctions
Link actin fibers in adjacent cells together
Desmosome
Attach to intermediate filaments of the cytoskeleton
The strongest cell-cell junctions
Focal Adhesion
Tie intracellular actin fibers to different matrix proteins
Hemidesmosome
Strong junctions that anchor intermediate fibers of the cytoskeleton to fibrous matrix proteins
Contribute to mechanical strength of the tissue
Cell Adhesion Molecules (CAMs)
Integrins
Primarily found in cell-matrix junctions
Cell signaling
Immunoglobulin Superfamily CAMs
NCAMs (nerve-cell adhesion molecules)
Responsible for nerve cell growth during nervous system development
Cadherins
Cell-cell junctions such as adherens junctions and desmosomes
Calcium-dependent
Selections
Temporary cell-cell adhesions
Communicating Junctions
Gap Junctions
Allow direct cell to cell communication
Allow both chemical and electrical signals to pass rapidly
Occluding Junctions
Tight Junctions
Block movement of material between cells