Please enable JavaScript.
Coggle requires JavaScript to display documents.
common rheumatological findings (Major immune players (TNF, IL23 (Lupus),…
common rheumatological findings
joint pain
size
small joints: RA (not DIP joints), viral arthritis (hepatitis B, parvovirus B19 - antigenic persistance)
symmetry
symmetric: RA
asymmetric: gout, OA, spondyloarthropathies
number
oligoarticular
polyarticular
monoarticular
WBCs in joint space
septic (>50,000 wbcs)
Bacterial
: gonococcal, non-gonococcal
Lyme disease
: HLA DR4 --> molecular mimicry between bug OspA and the human LAF1-alpha
Viral arthritis
: Hep B (IC mediated), parvovirus B19 (antigenic persistence)
inflammatory (2,000 - 10,000 wbcs)
RA, SLE, SpA, gout
non-inflammatory (200 - 20,000 wbcs)
OA
immune complexes
SLE
immune-complex mediated vasculitis (SSV)
Viral arthritis, hepatitis B
HLA haplotype associations
HLA B27: ankylosing spondylitis (AS)
HLA DRB1: rheumatoid arthritis
HLA DR4: Lyme resistance --> arthritis
Positive ANA
SLE
Anti-dsDNA, anti-Smith
Scleroderma
Anti-centromere (limited cutaneous)
Major immune players
TNF
IL23
Lupus
IFN
IL-1
IL-6
IL-13 (Hogkins)
IL-17
IL-22
TGF-beta
Scleroderma