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Non-coding RNA (ncRNA) networks in cancer (terminology (non-coding RNA…
Non-coding RNA (ncRNA) networks in cancer
terminology
non-coding RNA
produces functional regulatory molecules
mediate cellular processes
chromatin remodelling
transcription
post-trans mod
signal transduction
key regulators in important cellular programmes
networks
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in which
affect different molecular targets
drive specific reactions within cells
impossible to view in isolation
ncRNAs target the mRNAs of many other different genes
mRNA of each gene can be targeted by multiple miRNAs
miRNAs also functionally interact with other species of ncRNAs
circRNAs
regulate available miRNAs
sequestration
lncRNAs
.
regulate their stability
regulators
in cancer
ncRNAs
oncogenic drivers
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Therapeutic potential!
networks could be utilized to discover
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tumor suppressors
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cancer networks affected by ncRNA
network motifs
patterns of interactions
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transduce signals
composed of
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scale-free network
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network motifs that ncRNAs participate
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other patterns of ncRNA networks
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cellular processes and pathways
pathological contexts
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in developmental contexts
regulation of protein complexes
history
first small and temporal RNA
demonstrated that some RNAs
lacking protein coding regions
conserved functional molecules required for development
highly conserved
miRNAs
structure
ncRNA interactions conform to characteristic patterns, or motifs
found in complex networks of all types
network motifs