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Staphylococci (Virulence determinants (Surface proteins
Capsules
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Staphylococci
Virulence determinants
- Surface proteins
- Capsules
- Exoenzymes
- Proteases
- Exotoxins
- Immune-modulatory factors
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Capsular polsaccharides (potent abscess potentiators, prevents phagocytosis)
Immune evasion (prevention of phagocytosis, inhibits recruitment of neutrophil/monocyte to site of infection CHIPS, prevents complement activation SCIN)
Pyrogenic toxin superantigens, cytolytic toxins
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Coagulase test
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+ve: S.aureus, pseudintermedius, hyicus
-ve S. scuiri, equorum, epidermis
Staph. Pseudintermedius
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Otitis externa, abscess formation, mastitis, endocarditis, wound infections
Pyoderma - Alteratons of skin surface micro-enviro, trauma, allergic skin disease, breed associations. Almost always superficial but can be deep. Treatment - Antimicrobials. Recurring
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Staph. Aureus
Mastitis, endometritis (skin/soft tissue infection), osteomyelitis, endocarditis, pneumonia, septicaemia
Toxinoses - Food poisoning, scalded skin syndrome (SSSS), toxic shock syndrome (TSS)