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ISCHAEMIA (PATHOPHYSIOLOGY (FUNCTIONAL CHANGES (B. ANAEROBIC GLYCOLISIS…

- - - - DEPLETION ATP=FAILURE ATP PUMP
      - LEAKAGE OF PROTEINS
      - CELL DEATH
      - DENATURATION OF PROTEINS
      - FAILURE PROTEINSYNTHESIS
      - NUCLEUS=PYKNOSIS, KARYORRHEXIS & KARYOLYSIS
    - - STIMULATED BY NECROTIC DEBRIS
      - ISCHAEMIC AREA INFILTRATED BY INFLAMM. CELLS
- - - - AETIOLOGY =ATHEROMA
      - CLINICAL EFFECTS: INTERMITTENT CLAUDATION ( CRAMPING PAIN IN LIMB)
      - MACROSCOPICALLY: BEDSORES DUE TO COMPRESSION OF BV
      - MICROSCOPICALLY: INFARCTION
    - - DUE TO INCOMPLETE OCCLUSION OF CORONARY VESSELS AS A RESULT OF ATHEROMA (FAT DEPOSITS IN ARTERIES)
      - MICROSCOPICALLY: MYOCYTES LOST & REPLACED WITH FIBROUS TISSUE
      - MACROSCOPICALLY: SMALLER OVULATED ORGAN
      - CLINICAL EFFECTS: ANGINA