Please enable JavaScript.
Coggle requires JavaScript to display documents.
Acute Pancreatitis (Causes: Remember the mneumonic I GET SMASHED (T trauma…
Acute Pancreatitis
-
Diagnosis
-
-
-
-
-
Use Glasgow and Ranson scoring system. Looks at age, neutrophils, calcium and blood glucose
-
Clinical Presentation
-
Anorexia, nausea and vomiting are all symptoms
-
Shock symptoms: tachycardia, fever, jaundice, dehydration and hypotension
-
-
-
Definition: pancreatitis is the inflammation of the pancreas. This is due to a number of factors. It has specific clinical features. The pancreas is made up of exocrine cells (digestive enzymes --> common bile duct) and then the endocrine cells (secrete hormones)
-
-
-
-
-
Pathophysiology
This damage causes an activation of the pancreatic enzymes. This means that the pancreas is auto digested
In Gallstones this happens because there is an obstruction of enzyme-rich fluid out of the pancreas. There is early activation of trypsinogen
-
Alcohol-induced pancreatitis. Alcohol interferes withCa2+ homeostasis and means that there is a leakage of fluid into tissues causing oedema, inflammation and hypovolaemia (as liquid is stuck in gut, peritoneum and retroperitoneum) .This inflammation stimulates the activation of enzymes
Lipolytic enzymes cause fat necrosis that leads to skin discolouration (Grey Turner's sign) . The lipids also bind to Ca2+ ions meaning that hypocalciaemia can occur
-
-
-
Acute pancreatitis happens when there is no background of prior pancreatic problems. After the disease has been treated the pancreatic function can return to normal