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Glucocorticoids (Adverse Effects (Circulatory failure # # (must be weaned…
Glucocorticoids
Adverse Effects
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Increased risk of infection #
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At risk patients
Diabetes
- Older patients
- Osteoporosis # # #
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Psychologic disturbances, Aggressive behavior
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Effects
Pharmacologic effects high dose
Suppress Inflammation
Cardiovascular Effects
at LOW levels, so not while taking
increased permeability -> suppressed vasoconstriction -> BP drop
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Physiologic Effects low dose
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Effects during physiologic stress
such as surgery, infection, trauma
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Contraindications
systemic fungal infections #
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Molecular Mode of Action
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Modulate production of regulatory proteins, NOT signaling pathways
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