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Histamine (Anti-Histamines (drug class that antagonizes histamine's…
Histamine
Anti-Histamines
drug class that antagonizes histamine's effect
specifically block H1 receptors
NSAIDS
inhibit COX
Immunosuppressants
limit or inhibit the general immune response
Pro
treatment for autoimmune diseases
prevents transplant rejections
Cons
inc risk of infection
inc risk of malignancy
Glucocorticoids
first generation and second generation drugs
first generation is more sedative than the second generation
release by
basophils
mast cells
functions
binds to histamine receptors and initiates systemic effects
effects
vasodilation
increased vessel permeability
alertness
allergic-type reactions
itching
swelling
hives
hypotension
Histamine receptors
GPCR receptors
H1
H2
H3
H4