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Class 3B. Digestion and Absorption (organs/body parts for digestion (mouth…
Class 3B. Digestion and Absorption
Digestion and Absorption of Proteins
Proteases
pepsin
activated from pepsinogen by HCl
site-specific cleavage
trypsin
activated from trypsinogen
chymotrypsin
activated from chymotrypsinogen
elastase
activated from proelastase
Peptidases
aminopeptidase
carboxypeptidase
Digestion and Absorption of Vitamins and Metal ions
fat soluble vitamins
minerals
Digestion and Absorption of Carbohydrates
polysaccharides
starch
amylase
saliva
small intestine
disaccharides
lactose
lactase
small intestine
sucrose
sucrase
small intestine
maltose
maltase
small intestine
Digestion and Absorption of Lipids
Bile Salts
Physicochemical Properties
polar face AND non-polar face
amphiphilic
Function
Emulsification of lipids in food
stabilize mixed micelles
Synthesis
Precursor
cholesterol - bile acids
Re-absorption
also known as: Enterohepatic Circulation
absorbed towards the end of ileum of small intestine
carried in portal blood, bound to albumin
added to bile again by liver and secreted again through gallbladder
Hydrolysis
Triacylglycerol = Triglyceride
Enzyme: lipase
saliva
pancreas
Colipase
Phospholipids
Enzyme: phospholipases
Cholesteryl Ester
Enzyme: esterases
Absorption
simple diffusion
Post-absorptive transport
chylomicrons
Because of both limited solubility and detergent properties of free fatty acids
free fatty acids need to be re-esterified to less polar products for transport in the form of lipoprotein aggregates
free fatty acids released from adipocytes are transported in plasma bound to serum albumin,
the high concentrations of free fatty acids present after a meal would overwhelm the albumin transport system.
composition
triglyceride (84%)
other lipids and proteins
cholesterol
cholesteryl ester
phospholipids
apolipoproteins
organs/body parts for digestion
mouth (saliva)
amylase
lipase
stomach
pepsin
liver
bile salts
pancreas
produces
lipase
amylase
protease
small intestine
disaccharididase
peptidase
colon
Regulation of digestion
gastrin
cholecystokinin
secretin