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Antihistamines (Receptors H1 H2 (H1 Receptors 1) Vasodilation 2)…

- - - - First Generation = Diphenhydramine
        
        Uses:
        
        1) Mild Allergy
        2) Severe Allergy (Limited Benefits)
        3) Motion Sickness
        4) Insomia
        5) Common Cold - symptom relief only
        
        Adverse Effects
        
        1) Can't see, Can't pee, Can't spit, can't sh!t
        2) CNS
        a) Sedation b) dizziness, fatigue, coordination, confusion
        3) GI - N/V, loss of appetite, constipation
        4) severe respiratory depression
        5) local tissue injury
        
        High Risk Patients
        Third trimester
        nursing mothers
        newborns
        
        Use Caution with
        
        Young children
        older adults
        Patient who's condition may be aggravated by muscarinic blockade (ADD THESE CONDITIONS HERE)
        
        Conditions Made Worse by Muscarinic Blockade
      - Second Generation
        
        Cetirizine
        
        Teaching Points
        Food Delays absorption
        Most Sedating 2nd Gen but less than 1st Gen
        
        Fenofexadine
        
        Uses
        Seasonal Rhinitis
        Chronic idiopathic urticaria (Hives) #
        
        Offers Best combination of efficacy (effectiveness) and safety among second generation agents
        
        effectiveness can be reduced by certain fruit juices
        
        Loratadine
        
        Uses
        Only Seasonal Rhinitis
        
        Teaching Points
        Food Delays absorption
        Hepatic (liver) and Renal (kidney) impairment
- - - - no antidote
        Activated Charcoal
        Cathartic (flush system)
        hyperthermia
        for convulsions - IV benzodiazepines