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FUN1: Intro to Cell + Systems of Immune System (ii) (Cytokines…
FUN1: Intro to Cell + Systems of Immune System (ii)
Lymphoid Organs
Primary
Thymus + bone marrow
Lymphocyte maturation
Secondary
Lymph nodes, spleen, MALT
interaction between lymphoid cells + pathogen
zones of lymph node
germinal centres - B cells
Paracortex - T cells
Medulla - macrophages, dendritic cells, plasma cells
Communication between immune cells
soluble mediators
cell-to-cell via Rs
Cytokines
made by barrier cells
interleukins
2 + 12 = activators
1 + TNF = inflamm
23 = differentiation
interferons
Type 1 (alpha + beta) limit virus growth
Type 2 (gamma) activate phagocytes + limits virus/tumour growth
chemokines
attractants
rantes, IL8
colony stimulating factors
growth factors + differentiation cytokines
GMCSF, GCSF
bind to specific cell surface Rs + trigger gene expression