Fanconi Syndromes: Generalized re absorptive defect in PCT, associated with increased excretion of nearly all amino acids, glucose HCO3- and po43- - may result in metabolic acidosis (proximal renal tubular acidosis). Causes include hereditary defects (wilson disease, tyrosinemia, glycogen storage disease, ischemia, multiple myeloma, nephrotoxins, lead poisoning.