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integrin (ROLE OF ITEGRIN (CELL ADHHESSION, AID ECM, MODULATE GROWTH…
integrin
ROLE OF ITEGRIN
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receptors for spatially restricted extracellular ligands, including most of the structural components of the ECM and several matrix-associated growth factors and proteases
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IN HSCs
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INTEGRIN b3 SIGNALLING CONTRIBUTE TO THE MAINTENANCE OF HSCs BY STIMULATING LONG TERM REPOPULATING ACTIVITY, COLLABORATING WITH THROMBOPOIETIN, THE CYTOKINE WHICH HELPS IN MAITAINING QUIESCENCE AND PROLIFERATION
HSCs RESPOND TO SIGNALS FROM THEIR NICHE THROUGH A GROUP OF CELL SURFACE RECEPTORS, INTEGRIN IS ONE OF THEM
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reference;
1 Outside-in integrin signaling regulates
hematopoietic stem cell function via
Periostin-Itgav axis
2 Integrin avb3 enhances the suppressive effect of
interferon-c on hematopoietic stem cells