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2.1 NEUROTRANSMITTERS, DRUGS, POISONS (Neurotransmitters (Dopamine…
2.1 NEUROTRANSMITTERS, DRUGS, POISONS
Agonist
Antagonist
Neurotransmitters
Acetylcholine
Learning
Memory
Muscle movement
Alzheimer's - lack of
Botulinum poison
No ACH release at muscle junctures
Paralysis/ death
Black widow spider venom
Continuous ACH release
Flooding the synapse
Dopamine
Arousal
Mood states
Physical movement
Parkinson's - lack of
Movement problems
Blood-brain barrier (doesn't work)
L-dopa (works)
Side effects
Schizophrenia
Amphetamines
Agonists for dopamine
Cocaine
Blocks reuptake
Serotonin
Arousal and mood
Sleep
Eating
SSRI
Agonists
Norepinephrine
GABA
Main inhibitory
Glutamate
Main excitatory
Too much - strokes
Deficient - coma
Endorphins
Pain relief
Morphine + heroin
Antagonists
Increase endorphin activity
Pleasure