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Celecoxib (Indication (osteoarthritis, rheumatoid arthritis, dysmenorrhea,…
Celecoxib
Indication
osteoarthritis
rheumatoid arthritis
dysmenorrhea
acute pain
Adverse Effects
dyspepsia
risk of MI/Stroke
(overall lower for NSAIDS) but risk for GI bleeds
Contraindication
Warnings
w/ sulfonamide allergy
avoid in 3rd trimester in pregnancy
none
Drug Interactions
warfarin (INC ANTICOAGULANT effects)
other NSAIDS/other COX inhibitors => inc effect, additive effect
Mechanism of Action
selectively inhibits COX-2 (the molecules not present on platelets)
2nd gen NSAID