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Aspirin (Adverse Effects (Salicylism (dizziness, tinnitus, sweating,…
Aspirin
Adverse Effects
GI distress (including inc in GI bleeds
renal dysfunction
tinnitus
ringing in the ears
if under 18
Reyes Syndrome
Salicylism
dizziness
tinnitus
sweating
headaches
Indication
inflammation
inflammatory pain
fever
promotion of dec platelet aggregation (dec MI/ Stoke risk)
Drug Interactions
w/ anticoagulants
inc risk of bleeding
glucorticoids
inc risk of ulceration
Alcohol
inc risk of gastric ulcers
NSAIDS
can inhibit binding to COX-1 on platelets
Contraindication
pregnancy
discontinue 7-10 days b4 surgery (lifespan of platelets)
Mechanism
irreversibly inhibits COX (COX-1 > COX-2)
irreversible binding means new COX molecules must be synthesized for COX to have an effect
Drug Class: first gen NSAIDS