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Toxicity (Inappropriate repair and adaptation (Repair (Types of repairs…

- - - - Decreasing delivery to target
        
        Adaptation by increasing repair
  - - - Tissue--Apoptosis
      - Cellular: not popular, exception neurons
        Peripheral neurons can be repaired
        Central neuron damage irreversible, but partial compensation
  - - - when toxicant injury affects the repair process
      - when no effective system for needed type of repair
        toxicants become covalently bound to proteins
      - when needed enzymes/cofactors are depleted
      - Repair can contribute to injury
      - when damage overwhelms repair mechanisms
- - - - Dysregulation of transcription (DNA --> mRNA)
        Transcription factors/promotor regions may be affected