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WOUND HEALING (COMPLICATIONS (KELOID FORMATION, INFECTION, PYOGENIC…
WOUND HEALING
COMPLICATIONS
KELOID FORMATION
INFECTION
PYOGENIC GRANULOMA
CONTRACTURE
WOUND DEHISCENCE( RUPTURE ALONG SURGICAL INCISION)
DEPENDANT OF PROLIFERATIVE ABILITY OF CELLS
STABLE CELLS
LIMITED ABILITY TO REGEN.
IF CT INTACT= REGENERATION
IF CT NOT INTACT= REPAIR
E.G. PANCREAS, LIVER, KIDNEY, SMOOTH MUSCLE
LIABLE CELLS
CONTINUOUSLY REGEN.
E.G. MUCOSAL SURFACES, SKIN & BONE MARROW
PERMANENT CELLS
HEALS VIA REPAIR
RESULTS IN SCARRING
CAN'T REGENERATE
E.G. NEURONS, SKELETAL MUSCLE & CARDIAC MUSCLE
PHASES
PROLIFERATION
MATURATION
INFLAMMATION
SKIN
PRIMARY UNION
CLEAN CUT THRU. SKIN
2 SKINS JOINED BY FIBRIN PLUG
LATER REMOVED BY LYSIS TO ALLOW FOR RE-EPITHELISATION & RESTORATION OF SKIN
AKA: 1ST INTENTION
SECONDARY UNION
AKA: 2ND INTENTION
GAGGED CUT
CUTANEOUS WOUND
LARGER FIBRIN CLOT
FIBROBLASTS MIGRATE TO AREA & CAUSE COLLAGEN TO BE LAID
COLLAGEN THEN MATURES & RESTORES INTEGRITY OF SKIN
AFTER 12 WEEKS OF HEALING, 70-80% OF SKIN IS NORMAL
OCCURS BY TWO PROCESSES
REGENERATION
REPLACEMENT OF DAMAGED CELLS BY SAME CELL TYPE
THIS OCCURS BY PROLIFERATION OF UNINJURED CELLS & STEM CELL DIVISION TO FILL UP SIGHT OF DIVISION
REPAIR
DEPOSITION OF CT( FIBROSIS) FORMING SCAR TISSUE
FACTORS:
LOCAL
SCARRING
FOREIGN OBJECT
TUMOUR
INFECTION
BLOOD SUPPLY
EXCESS MOBILITY
POOR APPOSITION
SYSTEMIC
HORMONES
AGE
NUTRITION
GROWTH FACTORS
VEGF
ANGIOGENESIS
TGF-B
FIBROBLAST MIGRATION
COLLAGEN SYNTHE.
CHEMOTAXIS
NEURAL TISSUE
CNS
INJURY =LIQUEFACTIVE NECROSIS
MICROGLIAL CELLS CLEAR DEBRIS
NEURONS =PERMANENT CELLS
GLIAL SCAR FORMS( GLIOSIS)
PNS
SCHWANN CELLS GROW & UNTIE 2 ENDS
MACROPHAGES CLEAR UP DEBRIS
AXON BREAKS
GRANULATION TISSUE
NEW CT & MICROSCOPIC BV THAT FORM ON SURFACES OF OF A WOUND DURING HEALING PROCESS
RESTORATION TISSUE ARCHITECTURE & FUNCTION AFTER INJURY