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Cyclooxygenase (COX) (Functions (@ site of local injury (catalyzes…
Cyclooxygenase (COX)
Functions
@ site of local injury
catalyzes synthesis of PGE3 and PGD2
promotes inflammation, sensitize to pain
in stomach
promotes PGE2 and PGI2
protective function and keep gastric mucosa healthy
in blood vessels
promotes synthesis of PGI2 (prostacyclin)
inc vasodilation and dec platelet aggregation
in platelets
inc synthesis of TXA2
inc platelet aggregation
in kidneys
inc PGE2 and PGI2
inc vasodilation and renal blood flow
in brain
mediates fever and perception of pain
in uterus
promotes contractions
Types
COX-1
location
basically all tissues
main functions
protecting gastric mucosa
promoting renal funciton
promoting platelet aggregation
seen as generally good
inhibition
harmful effects
gastric ulcers
bleeding
renal impairment
beneficial effects
protection against myocardial infarction
reduced platelet aggregation
COX-2
location
@ sites of tissue injury
synthesized in response to tissue injury
generally bad
inhibition
generally good
suppresses inflammation
alleviation of pain
reduction of fever
protection against colorectal cancer
major bad side effects
renal impairment
promotion of myocardial infarction and stroke
main functions
mediates inflammation
sensitizes receptors to stimuli (including pain)
commonly found enzyme
created from phospholipids
created all over the body from the cell membrane (phospholipid bi-layer
Inhibited by
NSAIDS