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Drug Classes (Exam 1) (DMARDS (Biological DMARDS (TNF-(alpha) antagonists,…

- - - - TNF-(alpha) = a pro-inflammatory cytokine
      - released by macrophages and (some) by T cells
      - in high concentrations in RA patients and in tissues of patients w/ autoimmune diseases
      - effects inc MANY components assoc w/ immune response and mobilization and secretion of pro-inflamm molecules and immune cells
      - the antibodies bind to TNF-(alpha)
        
        cause macrophage and lymphocyte apoptosis, reduces cytokine production
    - - as antibodies, specifically target one type of antigen
      - Types of mABs
        
        murine
        
        chimeric
        
        humanized
        
        fully human
- - - - response to stress!!
      - drugs mainly mimic cortisol
        
        anti-inflammatory
        
        immunosuppressant
        
        VERY POWERFUL!
  - - - made from cholesterol in adrenal glands