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Pujol. Onset (abstract (AP recorded from oval window (cochlear (light and…
Pujol. Onset
abstract
AP recorded from oval window
VIII nerve
cochlear
light and el microscopy
Onset
organ of Corti
tunnel space
oppening
inner spiral sulcus
formation
tectorial membrane
separation
neuro-epithelial synapses
myelination and formation
2-3 days before
earliest cochlear potentials
Introduction
otocyst
precursor of the inner ear
cochlear microphonic
(CM)
action potential (AP)
onset
CM
guinea pigs :pig2:
15-12 D
BB
kittens :cat:
2 D
BB
puppies :dog2:
4-5 DAB
:rat:
P9
AP
kittens :cat:
0-2 DAB
puppies :dog2:
7-8 DAB
guinea :pig2:
12-8 DAB
:rat:
P12-16
later
stimuli
less intensivity
broader frequency spectrum
cochlea maturation
apical less developed
4 stages
[by time lag]
CM time
tectorial membrane detached
internal spiral
sulcus formed
“large swelling” had disappeared
:recycle: tunnel of Corti
AP time
hair cels adult-shaped
:check: tunnel of Corti
:check:Nuel’s space
Before onset
hair cells round-shaped
:check:stereocilia
:check:teclorial membrane
formed but still strongly attached
to hair and supporting cells
:no_entry:tunnel of Corti
:no_entry:Space of
Nuel
internal spiral sulcus
filled with
tall columnar cells
Adult
CMP
altering by
aminoglycoside antibiotics,
which affect the hair cells
CAP
altering by
Glu, AMPA, NMDA, kainate
reproduction of the waveform of the sound stimulus
in outer hair cells :question:
otoacoustic emission (OAE) is a sound which is generated from within the inner ear
ABR
(auditory brainstem response)
structures
