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Limbic System (hippocampal formation (hippocampus - memory consolidation…

- - - - px with Down sd commonly present alzheimer's in middle age > Chromosome 21 is one site of a defective gene
      - 60% of all cases of dementia
      - insidious onset (Anterograde amnesia), mood alterations, receptive aphasia (when Wernicke area is affected), apraxia, bedridden state.
      - 5-10% hereditary, autosomal dominant, early onset.
- - - - Hypermetamorphosis - visual stimuli are repeatedly approached as though they were new
      - Increased oral or exploratory behavior
      - Hypersexuality or loss of sexual preference
      - Psychic blindness/prosopagnosia
      - Placid to all external and visceral stimuli
      - Anterograde amnesia - hippocampus
- - - - :zap: Mammilary bodies
        
        :zap: Anterior nucleus of the thalamus
        
        :zap:Cingulate gyrus - frontal and parietal lobe, above CC
        
        via Cingulum
        
        Entorhinal cortex :zap:
        
        perforant pathway
- - - - ocular palsies - blur vision, confusion, gait ataxia
    - - anterograde amnesia, retrograde amnesia (MB, DMT), confabulation
      - irreversible/no neuronal regeneration with thiamine injections
    - - Hippocampus, mammilary bodies, dorsomedial nuclei of thalamus