Necrosis - types of necrosis differ primarily by the type of tissue affected

Gangrenous necrosis

Wet

Dry

Coagulative

Colliquative (Liquifaction)

Caseous

Gas

  • most common
  • area is mostly solid and composed of denatured protiens
  • in contrast to coagulative necrosis

4 steps

2) leading to the loss of plasma membrane's ability to maintain electrochemical gradiants

3) resulting in an influx of calcium ions and mitochondrial dysfunction

1) ischemic cellular injury

4) and then degradation of plasma membranes and nuclear structure.

seen in the ischemic heart and kidney

  • when the dissolution of dead cells occurs very quickly
  • a liquified area of lysosomal enzymes and dissolved tissue may result and form an abscess or cyst. tissue has pockets of liquid, bacteria, white cells and debris throughout it in cyst like sacs.

seen often in the brain

can result from a bacterial infection that triggers a localization of WBC's which can digest dead cells resulting in liquid debris

cutting off arterial blood flow to the extremities. ex. frost bite, small artery disease

characterized by slow spread, absence of infection, and line of demarkation around the affected area

lacks a line of demarcation

characterized y cold, swollen, pulseless area in which liquifaction is occuring

foul odour indiccates bactyerial action

spread is rapid and symptomatic symptoms occur

due to Clostridia infection - usually in large traumatic wounds

organisms digest healthy and damaged tissue and gas bubbles appear

bacteria such as clostrid .....

looks like cheese.

Lungs

Technically, it is a sub-class of coagulative necrosis

looks like egg whites.

fat necrosis

  • has its own history and terminology,

technically coagulative

technically colliquative