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Amino acid NTs (Common synaptic processes (1) Uptake of precursors, 2)…

- - - - GABAa
        
        open Cl- channels, causing influx
        
        antagonists: muscimol
      - GABAc
        
        subtype of GABAa
    - - GABAb
        
        presynaptic
        
        close Ca2+ channels, blocking the influx
        
        postynaptic
        
        open the K+ channels causing eflux
        
        antagonists: baclofen
  - - - anxiolytic
      - sedative
      - muscle relaxant
      - anticonvulsant
      - attenuation of autonomic endocrine response
      - clinical use
        
        Acute anxiety
        
        Insomnia
        
        Epilepsy
        
        Pre-medication in surgery
        
        sedative durin minor medical procedure
      - positive allosteric modulators
        
        Same amount of GABA --> larger postsynaptic response
- - - - NMDA
        
        agonists: Glutamate/Glycine (coagonist), NMDA
        *Glutamate alone won't activate receptor
        
        antagonists: AP5 (blocks glutamate binding site)
        7-CK (blocks glycine binding site)
        
        linked to Na+/Ca2+ channel blocked by Mg2+ ion, which pops out upon depolarisation
      - non-NMDA
        
        AMPA
        
        agonists: Glutamate, AMPA, Kainate
        
        antagonists: CNQX
        
        Na+ channel linked
        
        kainate
        
        agonists: Glutamate, Kainate, Domoic Acid
        
        antagonists: CNQX
    - - mGluRs
        
        Group I
        
        +PLC (IP3)
        
        Group II
        
        -AC (cAMP)
        
        Group II
        
        -AC (camp)
        
        agonist: ACPD