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Hypoxia (Biochemistry (Succinate/metabolomics, Membrane potential,…
Hypoxia
Biochemistry
Succinate/metabolomics
Membrane potential
Mitochondrial ROS
MnP brain uptake by mass spec
HIF-1a?
NAD/NADH
Interventions
MnP
MitoQ10
When, how much?
Recapitulate against known uncouplers, roteneone
Mimic injury by culturing under hypoxia then re-perfusing
Exact changes needed and time-course
Still in fluid still not complex brain
Justified rationale for when to start it relative to xenopus development
Outcome variables
Brain size
Synaptogenesis
Labelling
Global BDNF?
Later development
Mechanistic intervention
Mutate the sub-unit
MitoPQ
Over-express AOX