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ADME (Absorption (transcellular) (Assume drug is not fully absorbed until…

- - - - LogD - distribution co-efficient
        
        Needs to be greater than 5
        
        If most of drug is in octanol layer not lipid layer then it won't cross the membrane or be absorbed well. Speed of membrane crossing can alter the use of the drug.
      - Logp = [octanol]/water
        
        Sees how well drug is distributed into lipid layer
- - - - 1st order = rate of change of drug directly proportional to amount of drug in blood