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PK/PD (Bioavailability (Effecting factors: food in gut, coating on tablet,…
PK/PD
Bioavailability
Effecting factors: food in gut, coating on tablet, how well perfused the tissue is, vol of bile
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incomplete- tab not broken down properly, chemical attack, failure of absoprtion, metabolised
Vol of distribution
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Evans blue - 3.5l in blood
ethanol - 40L -in all tissues
inulin - 10l - water soluble
quinacrine - 50,000l - trapped in tissues
heparin - 4.2l
amoxycilin - 14l
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