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PPAP:
DNA,non-enveloped
免疫低下才生病 (環狀dsDNA
nuclues內複製 (多瘤Polyoma virus…
PPAP:
DNA,non-enveloped
免疫低下才生病
環狀dsDNA
nuclues內複製
乳突Papilloma virus
oncoprotein致癌蛋白:
E6 找 p53
E7 找 p105RB
--> cell immortalize
or 一般途徑: 大量繁殖,lytic infection/ abortive頓挫/ latent infection
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多瘤Polyoma virus
oncoprotein致癌蛋白:
Large T antigen 找 p53 + p105RB
regulate cell 成長,轉型
mRNA transcription, DNA replication
SV40: 猴子
BK, JC: 人
不導致Human cancer
BK/JC, aerosal, viremia
immunocompetent健全:Latent/ 清除
immunodeficiency:
BK:viruria
JC:CNS->PML
adenovirus
腺病毒
E1B找 p53
E1A找 pRB
Infection,影響:
1.lytic:黏表皮cell
2.latent:lymphoid cell
3.transforming人無
disease:
no human cancer
呼吸道疾病,conjunctivitis, gastroenteritis, cytitispanggu膀胱炎
只有軍人有live oral vaccine
4,5,7型 用於研究gene theraphy
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