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Respiratory (COPD (2 clinical features (Pink Puffers:
mid - 50's
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Respiratory
COPD
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Lumen can be blocked by:
Excessive secretions
Inflammation of mucous glands
Destruction of parenchyma leading to loss of elasticity
umbrella term including, bronchitis, emphysema and small airway disease
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Non-respiratory acidosis
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Compensation
Raised H+, Lower HCO3, Low pCO2
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Acid-base disorders
Alkalosis
hyper-excitability of neurons, muscle twitches
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Acidosis
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Confusion, disorientation, respiratory failure
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Compensation via:
Renal - alters bicarbonate reabsorption, acid excretion
Respiratory - hypo/hyper ventilation
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