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(IR (Wet Granulation (Lubricant (Ratio Intra:Extra, Extra Granular, Intra…
IR
Wet Granulation
% Drug Loading
Drug :Excipient Ratio
% Soluble Components
% in soluble Components
Disintegrant
Extra
Intra:Extra Ratio
Intra
Lubricant
Ratio Intra:Extra
Extra Granular
Intra Granular
Blending Time
Blending RPM
Bio-Modulator
IG
EG
IG to EG ratio
Method of Use
Dissolved in Binder fluid
In the bed over which binder sprayed
IG :EG
Ratio
Granule PSD
Binding Agent
Binder Solvent
Non Aqueous
Aqueous
Binder Fluid
Solution
Dispersion
% of Solvent in Solution
Binder Fluid Addition Time
Direct Compression
% Drug Loading
Drug :Excipient Ratio
% Soluble Excipient
Lubricant
Blending Time
Blending RPM
Disintegrant
Roller Compression
% Drug Loading
Drug :Excipient Ratio
% Soluble Excipient
Lubricant
Blending RPM
Blending Time
IG
EG
Disintegrant
IG
EG
Blending (Capsule)
DR
Coating
% Poreformer
Polymer Opening pH
% Plasticizer
Water Insoluble
Water Soluble
% DR Coating
Non Aqueous
Hydro-Alcoholic
Aqueous
Partial Neutralisation
% Seal Coating
Aqueous
Non Aqueous
Hydro-Alcoholic
Functional
Retard (Evident under Fasted state, Rabeprazole)
Protection
Bio Modulator
Degradation Inhibitor
Solubility Enhncer
Surfactant
Micro environmental pH
High Soluble Excipients (Manitol)
Coating Modifyiers
Base (Faster DR opening)
Acid (Delayed DR Opening)
Check the pH of Core
ER
Polymer Grade
Drug:Polymer Ratio
Floating Drug Delivery
Application
Prevent release in colon (antibiotic)
Absorption Window
pGp Substrate
Basic drugs with high acid solubility & precipitates in small intestine
Drugs ionizable from pH 5-8
Mechanism of Release
Erosion
Diffusion
Swelling
Floating
SD