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ASTHMA (Drugs used for treatment (Cromoglycate and nedocromil (called anti…
ASTHMA
Drugs used for treatment
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B2 adrenoceptor agonists
salbutamol, NA,formoterol
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Muscarinic antagonists
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ipotropium, bromide, atropine
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Pathogenesis
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subsequent exposure to allergen-cross linking of IgE opens Ca channels-elevated levels of Ca cause release of mediators
Mediators
eosinophil derived proteins, neuropeptides
kinins, complement components
histamine,leukotrienes,PAF and cytokines
ASTHMA
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FEATURES
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early phase response- involves cells which are resident of respiratory epithelium (mast cells) and pre-formed substance histamine
late phase: cells are recruited from circulation (eosinophils, basophils and T cells)
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PHASES
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Phase 3: remodelling
recruitment of eosinophils, neutrophils and macrophages-release factors that function to eliminate the irritant through release of chemotactic factors
Phase 1: acute phase
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once stimulated-produce vasoactive factors that lead to constriction of blood vessels and smooth muscle
Clinical phenotypes
Concordant disease
1)Early onset atopic asthma-concordant symptoms, inflammation and airway dysfunction
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Discordant symptoms
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2)Obese non-eosinophilic-later onset, female preponderance with high symptom expressiom
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