Please enable JavaScript.
Coggle requires JavaScript to display documents.
HISTAMINE ANTAGONISTS, PEPTIC ULCER (Tissue (H1 cause ileum contraction,…
HISTAMINE ANTAGONISTS, PEPTIC ULCER
HISTAMINE RECEPTORS
H2 receptors- acute allergic reaction, operate through Gs to increase cAMP production
-
H1 receptors- acute allergic reaction, operate throug Gq to cause increase in calcium levels
-
Agonist
-
H2 agonist: 4 methyl histamine, impromidine
-
Tissue
-
H2 atrial rate, acid secretion
-
-
second generation antagonist- selective, mostly H1 receptor
drugs cross blood brain barrier mediated by block of histamine receptors in CNS-have sedative action
newer anti-histamine have no sedative action: astemizole, terfenadin
selective H2 antagonists: cimetidine, ranitidine
-
-
ACTIONS
-
Endothelial cells
-
histamine cause fall in bp by increasing vascular permeability and relaxing arteriolar smooth muscle
-
-
-
-
Neutrotransmitters
-
cell bodies of histaminergic neuron in hypothalamus project to caudate, amygdala, hippocampus and central grey matter
-
-
-
-
-
PEPTIC ULCERS
complications: esophagitis (inflammation of eosphagus), esophageal strictures (narrowing), Barrett's esophagus (abnormal change in cell type)
formed by a balance of tissue damaging chemicals, tissue protective agents and inflammatory causing agents
symptoms: taste of acid in the back of mouth, heartburn, bad breathm ches pain, vomiting
-
Gastroesophagel reflux disease/GERD= long term condition where stomach contetns come back up into the esophagus
-
-
GASTRIC GLANDS
-
-
Cardiac glands- found in cardia of stomach, enclosing the opening where the esophagus joins the stomach
-
-
-
-
-
-